医師の船曳美也子です。
ご報告が遅くなりましたが、10月のアメリカ生殖医学会に参加、発表してきました。
胚盤胞のグレーディングと妊娠率の関係で、胚盤胞の評価には、内細胞塊、栄養外胚葉、胚胞腔の大きさで判定します。
妊娠率は、栄養外胚葉と相関する報告が多いのですが、今回当院での結果は、栄養外胚葉と同時に胚胞腔の大きさも相関しているというものです。
他に、Post graduate course lectureで卵子凍結の講義を一日受けました。質疑応答もあり、活発な意見交換がありました。
写真は議長と。来春日本にこられるそうで、和食を楽しみにされていました。
THE BLASTOCOELE STAGE AND TROPHECTODERM MORPHOLOGY GRADE PREDICT THE PREGNANCY RATE OF
BLASTOCYST TRANSFERS.
M. Funabiki,Oak Clinic, Osaka, Japan.
OBJECTIVE: The effect of blastocoele stage, trophectoderm (TE) morphology grade, and inner cell mass (ICM) morphology grade on the pregnancy rate in blastocyst transfers is controversial. Therefore, we have estimated the effects of these parameters.
DESIGN: Prospective cohort study.
MATERIALS AND METHODS: A prospective study was performed from January 2013 to March 2015 and included 843 patients (median age 35.6 years) with infertility in our clinic. Furthermore, embryos were obtained with the patients’ informed consent and were cultured to blastocyst stage (Day 5 – Day 7) before their use in blastocyst transfers. The primary outcome in the present study was the clinical pregnancy rate. Statistical analyses were conducted using univariate and multiple regression analyses. Significance was defined as p<0.05.
RESULTS: The pregnancy rate was 32.1%in the present study. Univariate regression analysis showed that the blastocoele stage (P<0.001) and TE morphology grade (P<0.001) to be correlated with pregnancy rate.
There was no significant association between the ICM grade and pregnancy rate (P=0.97). Multiple logistic regression analysis showed that blastocoele stage (P=0.0002) and TE morphology grade (P=0.002) were significantly associated with pregnancy rate but that patient age (P=0.22), the number of blastocyst transfers (P=0.80) and ICM morphology grade (P=0.29) were not.
CONCLUSIONS: Blastocoele stage and TE grading, but not ICM grading, are significantly correlated with the pregnancy rate for blastocyst transfers