It is everyone's wish to stay young and healthy forever.
However, as we age, our skin and physical strength decline, becoming more appropriate for our age.
So what causes aging? There are genes that are deeply involved in human aging and longevity.
That is the "sirtuin gene (longevity gene)."
Activation of this gene improves physical functions such as skin cells, physical strength, and fatigue, resulting in rejuvenation.
NMN infusion activates this sirtuin gene, helping you stay young forever and live a healthy life.
The official name is "nicotinamide mononucleotide."
NMN is a vitamin-like substance that is made naturally in the body.
However, as we age, the amount produced in our bodies decreases.
It is thought that aging begins when NMN decreases in the body, and physical and cognitive functions deteriorate.
Study after study has found that ingesting this NMN dramatically changes the appearance and function of the body like turning back the hands of a clock, and it has attracted worldwide attention as a "rejuvenation drug.
Incidentally, foods that contain a lot of NMN include edamame, broccoli, and cucumber, but in the case of broccoli, if you want to ingest 100 mg of NMN per day, you will need about 40 kg (about 2000 bunches).
NMN can be efficiently taken into the body through intravenous drip.
NMN has been suggested to potentially improve ovarian function, egg quality, and sperm quality.
１）Cell Prolif. 2022 Jul 10;55(11):e13303. doi: 10.1111/cpr.13303
Administration of nicotinamide mononucleotide improves oocyte quality of obese mice
Luyao Wang 1 2, Yurong Chen 1 2, Jiarui Wei 1 2, Fucheng Guo 1 2, Leyi Li 1 2, Zhen Han 1 2, Zhengzhu Wang 1 2, Haibo Zhu 3, Xiaoling Zhang 1 2, Ziyi Li 1 2, Xiangpeng Dai 1 2
２） 2020 Feb 11;30(6):1670-1681.e7. doi: 10.1016/j.celrep.2020.01.058.
NAD+ Repletion Rescues Female Fertility during Reproductive Aging
Michael J Bertoldo 1, Dave R Listijono 1, Wing-Hong Jonathan Ho 1, Angelique H Riepsamen 2, Dale M Goss 3, Dulama Richani 2, Xing L Jin 4, Saabah Mahbub 5, Jared M Campbell 5, Abbas Habibalahi 5, Wei-Guo Nicholas Loh 2, Neil A Youngson 3, Jayanthi Maniam 3, Ashley S A Wong 3, Kaisa Selesniemi 6, Sonia Bustamante 7, Catherine Li 3, Yiqing Zhao 2, Maria B Marinova 2, Lynn-Jee Kim 3, Laurin Lau 2, Rachael M Wu 8, A Stefanie Mikolaizak 9, Toshiyuki Araki 10, David G Le Couteur 11, Nigel Turner 3, Margaret J Morris 3, Kirsty A Walters 2, Ewa Goldys 5, Christopher O'Neill 4, Robert B Gilchrist 2, David A Sinclair 12, Hayden A Homer 13, Lindsay E Wu 14
３）Biomedicines. 2022 Jun 29;10(7):1544. doi: 10.3390/biomedicines10071544
Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice
Abbas Habibalahi 1,*, Jared M Campbell 1, Michael J Bertoldo 2,3, Saabah B Mahbub 1, Dale M Goss 3, William L Ledger 2, Robert B Gilchrist 2, Lindsay E Wu 3, Ewa M Goldys 1
４）2024 May;37(5):852-861. doi: 10.5713/ab.23.0379. Epub 2024 Apr 1.
β-Nicotinamide mononucleotide improves chilled ram sperm quality in vitro by reducing oxidative stress damage
Zhendong Zhu 1, Haolong Zhao 1, Qitai Yang 1, Yajing Li 1, RuYuan Wang 1, Adedeji Olufemi Adetunji 2, Lingjiang Min 1
５）Antioxidants (Basel). 2024 Apr 24;13(5):507. doi: 10.3390/antiox13050507
Supplementing Boar Diet with Nicotinamide Mononucleotide Improves Sperm Quality Probably through the Activation of the SIRT3 Signaling Pathway
Haize Zhang 1, Jiawen Chai 1, Chaoyue Cao 1, Xiaolin Wang 1, Weijun Pang 1
Cell Rep
No negative aspects have yet been discovered for NMN.
On the contrary, it is known to protect against eye diseases, hearing loss, and the liver and heart.
It sounds like a panacea, but it's a fact that laboratories around the world have confirmed.
The rejuvenating ingredient NMN is absorbed into the body and then delivered to every corner of the body where it is converted into a substance called NAD+.
NAD+ is present in the bodies of all living creatures and influences their youth and health, but it begins to decline in the late teens, and by the time we reach our 40s, it is reduced to half its peak level, causing us to lose our youthfulness.
Therefore, an effective way to increase NAD+ concentration in the body is to supplement its raw material, NMN.
Cite from the Thesis "Age-Associated Changes In Oxdative Stress and NAD Metabolism InHuman Tissue Figure4"
A preparation containing NMN is infused into either the left or right arm.
The process takes approximately 15-30 minutes.
*Although some effects can be seen even after a single treatment, those who wish to maintain health, prevent aging (anti-aging), and relieve fatigue can maintain the effects by continuing treatment once every 1-4 weeks.
1 session ¥13,200 (Tax included ¥14,520)
※ Separate consultation and injection technique fees will apply.
※ The cost for NMN drip therapy will remain ¥13,200 (Tax included ¥14,520) until February 28, 2025. Starting from March 1, 2025, the price will increase to ¥18,000 (Tax included ¥19,800).
Our NMN infusion uses the only NMN raw material "N-Pro Med™ (manufactured by Nordeste Inc.)", which has been confirmed safe in research and proven to increase NAD+ in the blood, and a strict quality maintenance system and manufacturing control are implemented in the production process.
The effects confirmed in a study by Professor Akinobu Goto (Hyogo University of Medicine, School of Medicine) and others are as follows.
Thesis summary： Safety of 300 mg of NMN administered intravenously. Intravenous NMN administration is considered safe and beneficial
Effectiveness
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Increases the longevity molecule NAD+ level in the blood by approximately 20% (see NAD+ level chart)
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Improve sleep quality
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Blood fat (TG level) decreased by approximately 75% (see TG level chart)
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Improving TG levels may lead to the prevention and treatment of fatty liver and diabetes-related diseases
In particular, the effect of reducing blood fat by approximately 75% after infusion has not been confirmed in previous studies of oral NMN administration, and is thought to be an effect unique to NMN infusion.
Reference thesis：
"Kimura et al., 2022 | Cureus Nicotinamide Mononucleotide Is Safety Metabolized and Signiflacantly Reduces Blood Triglyceride Levels in Healthy Individuals"
*It refers to the fact that no equivalent effect of NMN infusion has been reported prior to the publication of this thesis.
