Ovarian Anti-Aging

Ovarian aging is caused by factors such as aging and stress. As the ovaries age, ovarian reserve (AMH) and egg quality decline, which can lead to irregular menstrual cycles, decreased pregnancy rates, and an increased risk of miscarriage.

For women living in a stressful society or those hoping to conceive in the future, "ovarian anti-aging" is crucial in preventing ovarian aging.

By improving ovarian function, an increase in female hormone secretion and enhanced egg quality can be expected.

At Oak Clinic, we recommend ovarian anti-aging treatments that may help improve ovarian and endometrial function, as well as enhance regenerative capabilities.

1. DHEA (Dehydroepiandrosterone) Supplement

※Stock may not be available due to sourcing challenges.

DHEA is a hormone secreted by the adrenal glands, and its secretion decreases with age. Supplementing with DHEA may help improve ovarian function and regulate hormone balance.

Dosage:

Take one tablet once a day.

Cost

2. Glowmin (Testosterone Cream)

Glowmin is a topical cream containing testosterone, which helps regulate hormone levels in the body through absorption via the skin. It plays a crucial role in maintaining women's sexual function, bone density, and muscle mass.

Usage and dosage :

Apply 2 cm once a day to the arms and legs.

Cost

3. NMN Drip (Nicotinamide Mononucleotide)

NMN is a compound involved in cellular energy metabolism and contributes to improving the functional decline associated with aging. Administering it via IV enhances absorption efficiency, allowing for more effective treatment.

Treatment Method :

Duration: Approximately 15 to 30 minutes
Treatment interval: Once every 1 to 4 weeks

Cost (per session)

References:

Article review suggesting the safety and antioxidant effects of NMN in humans:
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.Adv Nutr.
2023 Nov;14(6):1416-1435.
https://www.sciencedirect.com/science/article/pii/S2161831323013595?via%3Dihub(External Site)

Study showing that NMN supplementation restored egg quality, embryo development, and reproductive function in aging mice:
NAD+ Repletion Rescues Female Fertility during Reproductive Aging.
Cell Rep. 2020 Feb 11;30(6):1670-1681.
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30083-8?_returnURL=
https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124720300838%3Fshowall%3Dtrue(External Site)

Study showing that NMN supplementation improved the ovarian condition and increased ovarian reserve in aging mice:
Nicotinamide mononucleotide supplementation rescues mitochondrial and energy metabolism functions and ameliorates inflammatory states in the ovaries of aging mice.
MedComm (2020). 2024 Sep 30;5(10):e727.
https://onlinelibrary.wiley.com/doi/10.1002/mco2.727(External Site)

4. PRDF (Platelet-Rich Plasma-Derived Factors)

PRDF is a treatment that involves extracting platelets from autologous blood, activating them, and using various growth factors released from the platelets. While Platelet-Rich Plasma (PRP) involves injecting the platelets themselves, PRDF only injects the factors derived from PRP. The growth factors contained in platelets are involved in cell proliferation and differentiation, angiogenesis, self-tissue repair, and anti-inflammatory effects.

Treatment Method :

Blood collection 20ml → Processing in the clinic (1–2 hours) → Injection into the ovaries or uterus
In the case of ovarian injection:
Injection is typically performed around days 5 to 10 of the menstrual cycle, or it can be done at any desired timing (under local anesthesia or intravenous sedation).
In the case of uterine injection:
Injection is typically performed around day 12 of the menstrual cycle. If desired, it is possible to prepare and inject again 2 to 3 days later (blood collection and associated costs are required each time).

Cost

References

Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP).
Aging (Albany NY). 2022 Mar 22;14(6):2513-2523. doi: 10.18632/aging.203972.

The Effects of Autologous Platelet-Rich Plasma on Pregnancy Outcomes in Repeated Implantation Failure Patients Undergoing Frozen Embryo Transfer: A Randomized Controlled Trial.
Reprod Sci. 2022 Mar;29(3):993-1000. doi: 10.1007/s43032-021-00669-1.

A narrative review of platelet-rich plasma (PRP) in reproductive medicine.
J Assist Reprod Genet. 2021 May;38(5):1003-1012. doi: 10.1007/s10815-021-02146-9.

5. Exosome extraction and ovarian injection

Exosomes are a type of extracellular vesicle secreted by cells, containing DNA, RNA, proteins, and other substances. They are present in nearly all body fluids, including blood, and are involved in intercellular communication by being taken up by target cells. In the ovaries, exosomes are suggested to play a role in follicular development, oocyte maturation, and hormone secretion.

Treatment Method :

Visit the clinic around days 5 to 10 of the menstrual cycle, blood collection of 10 ml → Processing in the clinic on the same day (approximately 1 hour) → Injection into the ovaries (under local anesthesia or intravenous sedation).

Cost

References:

Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD.
Stem Cell Res Ther. 2018 Aug 9;9(1):216. doi: 10.1186/s13287-018-0953-7.

Extracellular Vesicles Derived from Mesenchymal Stem Cells Recover Fertility of Premature Ovarian Insufficiency Mice and the Effects on their Offspring.
Cell Transplant. 2020 Jan-Dec:29:963689720923575. doi: 10.1177/0963689720923575.

Biological therapies for premature ovarian insufficiency: what is the evidence?
Front Reprod Health. 2023 Sep 7:5:1194575. doi: 10.3389/frph.2023.1194575.

The Emerging Roles and Therapeutic Potential of Extracellular Vesicles in Infertility.
Front Endocrinol (Lausanne). 2021 Oct 22:12:758206. doi: 10.3389/fendo.2021.758206.